diff --git a/lib/internal/modules/cjs/helpers.js b/lib/internal/modules/cjs/helpers.js
index 3c49ab0a5d8..fea3fbcf48d 100644
--- a/lib/internal/modules/cjs/helpers.js
+++ b/lib/internal/modules/cjs/helpers.js
@@ -176,16 +176,19 @@ function addBuiltinLibsToObject(object, dummyModuleName) {
       get: () => {
         const lib = dummyModule.require(name);
 
-        // Disable the current getter/setter and set up a new
-        // non-enumerable property.
-        delete object[name];
-        ObjectDefineProperty(object, name, {
-          __proto__: null,
-          get: () => lib,
-          set: setReal,
-          configurable: true,
-          enumerable: false
-        });
+        try {
+          // Override the current getter/setter and set up a new
+          // non-enumerable property.
+          ObjectDefineProperty(object, name, {
+            __proto__: null,
+            get: () => lib,
+            set: setReal,
+            configurable: true,
+            enumerable: false,
+          });
+        } catch {
+          // If the property is no longer configurable, ignore the error.
+        }
 
         return lib;
       },
diff --git a/test/parallel/test-cli-eval.js b/test/parallel/test-cli-eval.js
index dcc2b8fcde3..b993dd47414 100644
--- a/test/parallel/test-cli-eval.js
+++ b/test/parallel/test-cli-eval.js
@@ -354,3 +354,12 @@ child.exec(
   common.mustSucceed((stdout) => {
     assert.match(stdout, /^number/);
   }));
+
+// Regression test for https://github.com/nodejs/node/issues/45336
+child.execFile(process.execPath,
+               ['-p',
+                'Object.defineProperty(global, "fs", { configurable: false });' +
+                'fs === require("node:fs")'],
+               common.mustSucceed((stdout) => {
+                 assert.match(stdout, /^true/);
+               }));