diff --git a/src/middleware/secure-headers/index.test.ts b/src/middleware/secure-headers/index.test.ts
index 915d6e7d..2f3d9ad5 100644
--- a/src/middleware/secure-headers/index.test.ts
+++ b/src/middleware/secure-headers/index.test.ts
@@ -36,6 +36,7 @@ describe('Secure Headers Middleware', () => {
     expect(res.headers.get('Cross-Origin-Resource-Policy')).toEqual('same-origin')
     expect(res.headers.get('Cross-Origin-Opener-Policy')).toEqual('same-origin')
     expect(res.headers.get('Origin-Agent-Cluster')).toEqual('?1')
+    expect(res.headers.get('Permissions-Policy')).toBeNull()
     expect(res.headers.get('Content-Security-Policy')).toBeFalsy()
   })
 
@@ -48,6 +49,9 @@ describe('Secure Headers Middleware', () => {
           defaultSrc: ["'self'"],
         },
         crossOriginEmbedderPolicy: true,
+        permissionsPolicy: {
+          camera: [],
+        },
       })
     )
     app.get('/test', async (ctx) => {
@@ -72,6 +76,7 @@ describe('Secure Headers Middleware', () => {
     expect(res.headers.get('Cross-Origin-Opener-Policy')).toEqual('same-origin')
     expect(res.headers.get('Origin-Agent-Cluster')).toEqual('?1')
     expect(res.headers.get('Cross-Origin-Embedder-Policy')).toEqual('require-corp')
+    expect(res.headers.get('Permissions-Policy')).toEqual('camera=()')
     expect(res.headers.get('Content-Security-Policy')).toEqual("default-src 'self'")
   })
 
@@ -98,6 +103,7 @@ describe('Secure Headers Middleware', () => {
     expect(res.headers.get('X-Permitted-Cross-Domain-Policies')).toEqual('none')
     expect(res.headers.get('Cross-Origin-Resource-Policy')).toEqual('same-origin')
     expect(res.headers.get('Cross-Origin-Opener-Policy')).toEqual('same-origin')
+    expect(res.headers.get('Permissions-Policy')).toBeNull()
     expect(res.headers.get('Origin-Agent-Cluster')).toEqual('?1')
   })
 
@@ -154,6 +160,28 @@ describe('Secure Headers Middleware', () => {
     expect(res.headers.get('X-XSS-Protection')).toEqual('1')
   })
 
+  it('should set Permission-Policy header', async () => {
+    const app = new Hono()
+    app.use(
+      '/test',
+      secureHeaders({
+        permissionsPolicy: {
+          fullscreen: ['self'],
+          bluetooth: ['none'],
+          payment: ['self', 'example.com'],
+          syncXhr: [],
+          camera: false,
+          microphone: true,
+          geolocation: ['*'],
+        },
+      })
+    )
+
+    const res = await app.request('/test')
+    expect(res.headers.get('Permissions-Policy')).toEqual(
+      'fullscreen=(self), bluetooth=(none), payment=(self example.com), sync-xhr=(), camera=none, microphone=(), geolocation=(*)'
+    )
+  })
   it('CSP Setting', async () => {
     const app = new Hono()
     app.use(
diff --git a/src/middleware/secure-headers/permissions-policy.ts b/src/middleware/secure-headers/permissions-policy.ts
new file mode 100644
index 00000000..f63593ec
--- /dev/null
+++ b/src/middleware/secure-headers/permissions-policy.ts
@@ -0,0 +1,86 @@
+// https://github.com/w3c/webappsec-permissions-policy/blob/main/features.md
+
+export type PermissionsPolicyDirective =
+  | StandardizedFeatures
+  | ProposedFeatures
+  | ExperimentalFeatures
+
+/**
+ * These features have been declared in a published version of the respective specification.
+ */
+type StandardizedFeatures =
+  | 'accelerometer'
+  | 'ambientLightSensor'
+  | 'attributionReporting'
+  | 'autoplay'
+  | 'battery'
+  | 'bluetooth'
+  | 'camera'
+  | 'chUa'
+  | 'chUaArch'
+  | 'chUaBitness'
+  | 'chUaFullVersion'
+  | 'chUaFullVersionList'
+  | 'chUaMobile'
+  | 'chUaModel'
+  | 'chUaPlatform'
+  | 'chUaPlatformVersion'
+  | 'chUaWow64'
+  | 'computePressure'
+  | 'crossOriginIsolated'
+  | 'directSockets'
+  | 'displayCapture'
+  | 'encryptedMedia'
+  | 'executionWhileNotRendered'
+  | 'executionWhileOutOfViewport'
+  | 'fullscreen'
+  | 'geolocation'
+  | 'gyroscope'
+  | 'hid'
+  | 'identityCredentialsGet'
+  | 'idleDetection'
+  | 'keyboardMap'
+  | 'magnetometer'
+  | 'microphone'
+  | 'midi'
+  | 'navigationOverride'
+  | 'payment'
+  | 'pictureInPicture'
+  | 'publickeyCredentialsGet'
+  | 'screenWakeLock'
+  | 'serial'
+  | 'storageAccess'
+  | 'syncXhr'
+  | 'usb'
+  | 'webShare'
+  | 'windowManagement'
+  | 'xrSpatialTracking'
+
+/**
+ * These features have been proposed, but the definitions have not yet been integrated into their respective specs.
+ */
+type ProposedFeatures =
+  | 'clipboardRead'
+  | 'clipboardWrite'
+  | 'gemepad'
+  | 'sharedAutofill'
+  | 'speakerSelection'
+
+/**
+ * These features generally have an explainer only, but may be available for experimentation by web developers.
+ */
+type ExperimentalFeatures =
+  | 'allScreensCapture'
+  | 'browsingTopics'
+  | 'capturedSurfaceControl'
+  | 'conversionMeasurement'
+  | 'digitalCredentialsGet'
+  | 'focusWithoutUserActivation'
+  | 'joinAdInterestGroup'
+  | 'localFonts'
+  | 'runAdAuction'
+  | 'smartCard'
+  | 'syncScript'
+  | 'trustTokenRedemption'
+  | 'unload'
+  | 'verticalScroll'
diff --git a/src/middleware/secure-headers/secure-headers.ts b/src/middleware/secure-headers/secure-headers.ts
index 3ef52aa0..902b45f7 100644
--- a/src/middleware/secure-headers/secure-headers.ts
+++ b/src/middleware/secure-headers/secure-headers.ts
@@ -6,6 +6,7 @@
 import type { Context } from '../../context'
 import type { MiddlewareHandler } from '../../types'
 import { encodeBase64 } from '../../utils/encode'
+import type { PermissionsPolicyDirective } from './permissions-policy'
 
 export type SecureHeadersVariables = {
   secureHeadersNonce?: string
@@ -54,6 +55,12 @@ interface ReportingEndpointOptions {
   url: string
 }
 
+type PermissionsPolicyValue = '*' | 'self' | 'src' | 'none' | string
+
+type PermissionsPolicyOptions = Partial<
+  Record<PermissionsPolicyDirective, PermissionsPolicyValue[] | boolean>
+>
+
 type overridableHeader = boolean | string
 
 interface SecureHeadersOptions {
@@ -73,6 +80,7 @@ interface SecureHeadersOptions {
   xPermittedCrossDomainPolicies?: overridableHeader
   xXssProtection?: overridableHeader
   removePoweredBy?: boolean
+  permissionsPolicy?: PermissionsPolicyOptions
 }
 
 type HeadersMap = {
@@ -108,6 +116,7 @@ const DEFAULT_OPTIONS: SecureHeadersOptions = {
   xPermittedCrossDomainPolicies: true,
   xXssProtection: true,
   removePoweredBy: true,
+  permissionsPolicy: {},
 }
 
 type SecureHeadersCallback = (
@@ -154,6 +163,7 @@ export const NONCE: ContentSecurityPolicyOptionHandler = (ctx) => {
  * @param {overridableHeader} [customOptions.xPermittedCrossDomainPolicies=true] - Settings for the X-Permitted-Cross-Domain-Policies header.
  * @param {overridableHeader} [customOptions.xXssProtection=true] - Settings for the X-XSS-Protection header.
  * @param {boolean} [customOptions.removePoweredBy=true] - Settings for remove X-Powered-By header.
+ * @param {PermissionsPolicyOptions} [customOptions.permissionsPolicy] - Settings for the Permissions-Policy header.
  * @returns {MiddlewareHandler} The middleware handler function.
  *
  * @example
@@ -175,6 +185,13 @@ export const secureHeaders = (customOptions?: SecureHeadersOptions): MiddlewareH
     headersToSet.push(['Content-Security-Policy', value as string])
   }
 
+  if (options.permissionsPolicy && Object.keys(options.permissionsPolicy).length > 0) {
+    headersToSet.push([
+      'Permissions-Policy',
+      getPermissionsPolicyDirectives(options.permissionsPolicy),
+    ])
+  }
+
   if (options.reportingEndpoints) {
     headersToSet.push(['Reporting-Endpoints', getReportingEndpoints(options.reportingEndpoints)])
   }
@@ -255,6 +272,30 @@ function getCSPDirectives(
       ]
 }
 
+function getPermissionsPolicyDirectives(policy: PermissionsPolicyOptions): string {
+  return Object.entries(policy)
+    .map(([directive, value]) => {
+      const kebabDirective = camelToKebab(directive)
+
+      if (typeof value === 'boolean') {
+        return `${kebabDirective}=${value ? '()' : 'none'}`
+      }
+
+      if (Array.isArray(value)) {
+        const allowlist = value.length === 0 ? '()' : `(${value.join(' ')})`
+        return `${kebabDirective}=${allowlist}`
+      }
+
+      return ''
+    })
+    .filter(Boolean)
+    .join(', ')
+}
+
+function camelToKebab(str: string): string {
+  return str.replace(/([a-z\d])([A-Z])/g, '$1-$2').toLowerCase()
+}
+
 function getReportingEndpoints(
   reportingEndpoints: SecureHeadersOptions['reportingEndpoints'] = []
 ): string {