diff --git a/django/db/models/query.py b/django/db/models/query.py
index 3f9d4768f7..b5c1cf6e78 100644
--- a/django/db/models/query.py
+++ b/django/db/models/query.py
@@ -1101,6 +1101,8 @@ class QuerySet(AltersData):
         """
         if self.query.is_sliced:
             raise TypeError("Cannot use 'limit' or 'offset' with in_bulk().")
+        if not issubclass(self._iterable_class, ModelIterable):
+            raise TypeError("in_bulk() cannot be used with values() or values_list().")
         opts = self.model._meta
         unique_fields = [
             constraint.fields[0]
diff --git a/tests/lookup/tests.py b/tests/lookup/tests.py
index 28acd72874..68adbe6496 100644
--- a/tests/lookup/tests.py
+++ b/tests/lookup/tests.py
@@ -327,6 +327,13 @@ class LookupTests(TestCase):
         with self.assertRaisesMessage(TypeError, msg):
             Article.objects.all()[0:5].in_bulk([self.a1.id, self.a2.id])
 
+    def test_in_bulk_not_model_iterable(self):
+        msg = "in_bulk() cannot be used with values() or values_list()."
+        with self.assertRaisesMessage(TypeError, msg):
+            Author.objects.values().in_bulk()
+        with self.assertRaisesMessage(TypeError, msg):
+            Author.objects.values_list().in_bulk()
+
     def test_values(self):
         # values() returns a list of dictionaries instead of object instances --
         # and you can specify which fields you want to retrieve.