diff --git a/Lib/test/signalinterproctester.py b/Lib/test/signalinterproctester.py
index cdcd92a8baa..073c078f45f 100644
--- a/Lib/test/signalinterproctester.py
+++ b/Lib/test/signalinterproctester.py
@@ -1,3 +1,4 @@
+import gc
 import os
 import signal
 import subprocess
@@ -59,6 +60,13 @@ class InterProcessSignalTests(unittest.TestCase):
         self.assertEqual(self.got_signals, {'SIGHUP': 1, 'SIGUSR1': 0,
                                             'SIGALRM': 0})
 
+        # gh-110033: Make sure that the subprocess.Popen is deleted before
+        # the next test which raises an exception. Otherwise, the exception
+        # may be raised when Popen.__del__() is executed and so be logged
+        # as "Exception ignored in: <function Popen.__del__ at ...>".
+        child = None
+        gc.collect()
+
         with self.assertRaises(SIGUSR1Exception):
             with self.subprocess_send_signal(pid, "SIGUSR1") as child:
                 self.wait_signal(child, 'SIGUSR1')
diff --git a/Misc/NEWS.d/next/Tests/2023-09-28-18-14-52.gh-issue-110033.2yHMx0.rst b/Misc/NEWS.d/next/Tests/2023-09-28-18-14-52.gh-issue-110033.2yHMx0.rst
new file mode 100644
index 00000000000..fb608937708
--- /dev/null
+++ b/Misc/NEWS.d/next/Tests/2023-09-28-18-14-52.gh-issue-110033.2yHMx0.rst
@@ -0,0 +1,5 @@
+Fix ``test_interprocess_signal()`` of ``test_signal``. Make sure that the
+``subprocess.Popen`` object is deleted before the test raising an exception
+in a signal handler. Otherwise, ``Popen.__del__()`` can get the exception
+which is logged as ``Exception ignored in: ...`` and the test fails. Patch by
+Victor Stinner.